Immunogenetic mechanisms driving norovirus GII.4 antigenic variation.
Noroviruses are the principal cause of epidemic gastroenteritis worldwide with GII.4 strains accounting for 80% of infections.The major Glass Blunts capsid protein of GII.4 strains is evolving rapidly, resulting in new epidemic strains with altered antigenic potentials.To test if antigenic drift may contribute to GII.4 persistence, human memory B c